Two sample MR report
LGALS2_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0432124 | 0.0492554 | 0.4058911 |
| Weighted median | 10 | 0.0261797 | 0.0074857 | 0.0004700 |
| Inverse variance weighted | 10 | 0.0235716 | 0.0060754 | 0.0001045 |
| Simple mode | 10 | 0.0278059 | 0.0113598 | 0.0368929 |
| Weighted mode | 10 | 0.0278059 | 0.0117038 | 0.0415127 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.406800 | 8 | 0.9941495 |
| Inverse variance weighted | 1.568261 | 9 | 0.9966080 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0126224 | 0.0314129 | 0.6983355 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005877 | 0 | TRUE | 0.0211443 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
